| MTND4 | OKDB#: 1068 |
| Symbols: | ND4 | Species: | human | ||
| Synonyms: | MTND4 | Locus: |
|
For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment |
Non-nuclear///////////Subunit 4 is 1 of the 7 mitochondrial DNA (mtDNA)-encoded subunits (MTND1, MTND2, MTND3, MTND4L, MTND4,
MTND5, MTND6) included among the approximately 41 polypeptides of respiratory complex I (NADH:ubiquinone
oxidoreductase, EC 1.6.5.3 ) .///////Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Wang S et al. (2020) Molecular mechanisms of ovarian aging and female age-related fertility decline remain unclear. We surveyed the single-cell transcriptomic landscape of ovaries from young and aged non-human primates (NHPs) and identified seven ovarian cell types with distinct gene-expression signatures, including oocyte and six types of ovarian somatic cells. In-depth dissection of gene-expression dynamics of oocytes revealed four subtypes at sequential and stepwise developmental stages. Further analysis of cell-type-specific aging-associated transcriptional changes uncovered the disturbance of antioxidant signaling specific to early-stage oocytes and granulosa cells, indicative of oxidative damage as a crucial factor in ovarian functional decline with age. Additionally, inactivated antioxidative pathways, increased reactive oxygen species, and apoptosis were observed in granulosa cells from aged women. This study provides a comprehensive understanding of the cell-type-specific mechanisms underlying primate ovarian aging at single-cell resolution, revealing new diagnostic biomarkers and potential therapeutic targets for age-related human ovarian disorders. Expression of this gene is highest in primordial oocytes//////////////////
|
||||
| General function | Metabolism, Enzyme | ||||
| Comment | |||||
| Cellular localization | Mitochondrial | ||||
| Comment | |||||
| Ovarian function | |||||
| Comment | |||||
| Expression regulated by | FSH | ||||
| Comment | Clouscard-Martinato C et al 1998 reported the characterization of FSH-regulated genes isolated by mRNA differential display from pig ovarian granulosa cells. They have isolated FSH-regulated genes from primary granulosa cell cultures with or without Follicle Stimulating Hormone (FSH) treatment using mRNA differential display. mRNA differential display consists of amplification of partial sequences of cDNAs (150-400 bp) corresponding to 3' ends of cellular messenger RNAs, and thus, generates 3' expressed sequence tags (3' ESTs). Five thousand cDNA bands were examined, among which the present authors have isolated and sequenced 16 different FSH-regulated products. These sequences were compared with those available in databases. Three of the sequences showed similarity to identified genes from other species (bovine NADH dehydrogenase subunit 4, Xenopus chromosome sequence-associated polypeptide E and transformation-sensitive protein IEF SSP). Regulation of the corresponding genes has been checked by RT-PCR since most of these are expressed at a low level. | ||||
| Ovarian localization | Oocyte, Granulosa | ||||
| Comment | |||||
| Follicle stages | |||||
| Comment | |||||
| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
|
| created: | Nov. 24, 2000, 2:53 p.m. | by: |
hsueh email:
home page: |
| last update: | Aug. 4, 2020, 1:29 p.m. | by: | hsueh email: |
Click here to return to gene search form