Fibulin-2 is a new extracellular matrix protein that we recently identified by
characterizing mouse cDNA clones. Fibulin-2 mRNA is prominently expressed in
mouse heart tissue and is present in low amounts in other tissueshe protein predicted from the cDNA obtained from
a mouse fibroblast library consisted of a 1,195-residue polypeptide preceded by a 26-residue signal
peptide. Except for 2 additional EGF-like repeats, the COOH-terminal region showed 43% sequence
identity with fibulin-1. The NH2-terminal 408 residues, unique to fibulin-2, showed no sequence
homology to other known proteins and presumably formed 2 additional domains that differ in their
cysteine content. Recombinant fibulin-2 was produced and secreted by human cell clones as a
disulfide-bonded trimer.
NCBI Summary:
Fibulin-2 is an extracellular matrix protein containing 3 consecutive anaphylatoxin-related segments in its central region followed by 10 EGF-like repeats, 9 of which had a consensus sequence for calcium binding. It may regulate interactions between adhesion receptors and the cytoskeleton.
General function
Cell adhesion molecule
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Cellular localization
Extracellular Matrix, Secreted
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Ovarian function
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Expression regulated by
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Ovarian localization
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Northern blot analysis of fibulin 2 mRNA from various human tissues reveals
an abundant 4.5-kb transcript in heart, placenta, and ovary tissue Zhang et al 1994 .