The SRY and SOX proteins share a DNA-binding domain known as the HMG box, defined by a 79-amino acid
region. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending
of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and
interactions of other transcription factors.
General function
Nucleic acid binding, DNA binding, Transcription factor
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Cellular localization
Nuclear
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Ovarian function
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Expression regulated by
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Ovarian localization
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Komatsu N, et al reported the cloning and expression of Xenopus laevis xSox12 cDNA.
They isolated and sequenced
a cDNA encoding xSox12 from Xenopus laevis ovary. The cDNA contained an open
reading frame (ORF) coding for 470 amino acids encompassing an HMG box
characteristic of the SOX family, a leucine zipper motif and glutamine-rich segments.
The size of the xSox12 mRNA was determined to be 3.0 knt by Northern analysis. The
ovary was the most prominent in the expression of the Sox mRNA among the various
tissues of adult frog as far as examined.