Chromosomal protein HMG14 and its close analog HMG17 bind to the inner side of the
nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be
involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous
distribution, relative abundance, and high evolutionary conservation of the DNA-binding domain of the HMG-14 family
of proteins, suggest that they may be involved in an important cellular function. The human HMG14 multigene family is
1 of the largest retropseudogene families known.
NCBI Summary:
Member of the HMG 14/17 family of proteins; may bind DNA with low specificity; shares a common DNA-binding motif with other HMG 1/2 family members
General function
Cell death/survival, DNA Replication, Nucleic acid binding, DNA binding, Transcription factor
Comment
Cellular localization
Nuclear
Comment
Ovarian function
Oogenesis
Comment
Mohamed OA, et al 2001 reported that
High-mobility group proteins 14 and 17 maintain the timing of
early embryonic development in the mouse.
The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal
proteins that bind to nucleosomes and enhance transcription. The authors reported that
both mRNA species and both proteins are present throughout oogenesis and
preimplantation development of the mouse.. The results identify HMG-14 and HMG-17 as constitutive components
of mouse oocyte and embryonic chromatin and establish a link between the
structure of embryonic chromatin and the normal progression of embryonic
development.