| Lysyl oxidase-like 3 | OKDB#: 1140 |
| Symbols: | LOXL3 | Species: | human | ||
| Synonyms: | Locus: |
|
For retrieval of Nucleotide and Amino Acid sequences please go to:
UCSC Genome Browser
GEO Profiles
new!
Amazonia (transcriptome data)
new!
R-L INTERACTIONS MGI |
| General Comment |
Lysyl oxidase (protein-lysine 6-oxidase; EC 1.4.3.13 ) is an extracellular copper
enzyme that initiates the crosslinking of collagens and elastin by catalyzing oxidative
deamination of the epsilon-amino group in certain lysine and hydroxylysine residues
of collagens and lysine residues of elastin.
Maki JM, et al 2001 reported the cloning
and characterization of a fourth human lysyl
oxidase isoenzyme.
They report the complete cDNA sequence and exon-intron organization of
the human lysyl oxidase-like (LOXL)3 gene, a new member
of the lysyl
oxidase (LO) gene family.
|
|||
| General function | Enzyme, Oxidoreductase | |||
| Comment | ||||
| Cellular localization | Extracellular Matrix, Secreted | |||
| Comment | ||||
| Ovarian function | ||||
| Comment | Maki JM, et al 2001 reported the complete cDNA sequence and exon-intron organization of the human lysyl oxidase-like (LOXL)3 gene, a new member of the lysyl oxidase (LO) gene family. The predicted polypeptide is 753 amino acids in length, including a signal peptide of 25 residues. The C-terminal region, residues 529-729, contains a LO domain similar to those in the LOX (the first characterized LO isoenzyme), LOXL and LOXL2 polypeptides. It possesses the putative copper binding sequence, and the lysine and tyrosine residues that form the lysyltyrosyl quinone cofactor. The N-terminal region, which is similar to that in LOXL2 but not those in LOX and LOXL, contains four subregions similar to scavenger receptor cysteine-rich domains and a putative nuclear localization signal. Recombinant LOXL3, expressed in HT-1080 cells, was secreted into the culture medium but was not detected by immunofluorescence staining in nuclei. The LOXL3 mRNA is 3.1 kb in size and is expressed in many tissues, the highest levels among the tissues studied being seen in the placenta, heart, ovary, testis, small intestine and spleen. | |||
| Expression regulated by | ||||
| Comment | ||||
| Ovarian localization | ||||
| Comment | ||||
| Follicle stages | ||||
| Comment | ||||
| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
| Links |
|
| created: | April 9, 2001, 11:17 a.m. | by: |
hsueh email:
home page: |
| last update: | Aug. 13, 2001, 3:52 p.m. | by: | hsueh email: |
Click here to return to gene search form