| NUB1 | OKDB#: 1144 |
| Symbols: | NUB1 | Species: | human | ||
| Synonyms: | Locus: |
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R-L INTERACTIONS MGI |
| General Comment |
Kito K, et al 2001 reported that NUB1, a NEDD8-interacting protein, is induced by interferon
and downregulates the NEDD8 expression.
NEDD8, a ubiquitin-like protein, covalently conjugates to cullin family
members. It appears to control vital biological events through its conjugation to
cullins. To study how this conjugation pathway is regulated, the authors performed
yeast two-hybrid screening by using NEDD8 as a bait and isolated a cDNA
fragment encoding a potent downregulator of the NEDD8 expression. NUB1 (NEDD8 Ultimate Buster-1) is
composed of 601 residues with a calculated 69.1-kDa molecular mass. It is an
interferon-inducible protein and predominantly localized in the nucleus. The
NUB1 message is specifically expressed in adult human testis, ovary, heart,
and skeletal muscle tissues and is developmentally downregulated in mouse
embryos. Overexpression
of NUB1 had a profound growth-inhibitory effect on U2OS cells. Thus,
NUB1 is a strong downregulator of the NEDD8 expression and appears to
play critical roles in regulating biological events, including cell growth.
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| General function | Intracellular signaling cascade, Cell death/survival, Apoptosis, Cell cycle regulation | |||
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| Cellular localization | Nuclear | |||
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| Ovarian function | ||||
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| Expression regulated by | ||||
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| Ovarian localization | ||||
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| Follicle stages | ||||
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| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
| Links |
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| created: | April 15, 2001, 4:33 p.m. | by: |
hsueh email:
home page: |
| last update: | Aug. 14, 2001, 1:36 p.m. | by: | hsueh email: |
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