Multidrug-resistant (MDR) cancer cells frequently overexpress the 110-kD lung resistance-related protein (LRP).
Overexpression of LRP often predicts a poor response to chemotherapy.
NCBI Summary:
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
General function
Channel/transport protein
Comment
Cellular localization
Plasma membrane
Comment
Ovarian function
Oogenesis
Comment
): Takebayashi Y, et al 2001 reported the expression of multidrug resistance associated transporters
(MDR1, MRP1, LRP and BCRP) in porcine oocyte.
Transporters such as P-glycoprotein (MDR1), multidrug resistance protein 1 (MRP1), lung resistance-related protein (LRP) and breast cancer resistance protein (BCRP) are associated with multidrug resistance in various carcinoma
cell lines. The expression of these molecules has been also characterized in human normal tissues. Their expression in porcine oocyte were examined by
reverse transcriptase-polymerase chain reaction. MDR1, MRP1 and LRP genes, but not BCRP gene were found to be expressed in porcine oocyte.