Stanford Home
Ovarian Kaleidoscope Database (OKdb)

Home

History

Transgenic Mouse Models

INFORGRAPHICS

Search
Submit
Update
Chroms
Browse
Admin

Hsueh lab

HPMR

Visits
since 01/2001:
176557

S100 Calcium-binding Protein A10 OKDB#: 1177
 Symbols: S100A10 Species: human
 Synonyms: CALPACTIN I, LIGHT CHAIN, CAL1L| CALPACTIN I, p11 SUBUNIT, CLP11| ANNEXIN II LIGAND, ANX2LG|  Locus: 1q21 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
Mammalian Reproductive Genetics   Endometrium Database Resource   Orthologous Genes   UCSC Genome Browser   GEO Profiles new!   Amazonia (transcriptome data) new!

R-L INTERACTIONS   MGI

DNA Microarrays
SHOW DATA ...
link to BioGPS
General Comment P11, also known as 42C or calpactin I light chain, belongs to the S100 family of calcium-binding proteins . The response to elevation of cytoplasmic Ca(2+) levels following extra- or intracellular stimuli is mediated by proteins that are capable of binding divalent calcium ions. A particular class of these proteins is characterized by the so-called EF-hand, a helix-loop-helix motif involved in coordinating the Ca(2+) ion. Within the EF-hand superfamily, a distinct set of proteins is grouped in the so-called S-100 protein family, whose members share a high degree of sequence similarity with S-100A and S-100B, Ca(2+)-binding proteins originally isolated from cerebrospinal fluid. Protein p11 (calpactin I, light chain) is a member of the S-100 family but has several unique features. It has suffered crucial deletions and amino acid substitutions which are thought to render both Ca(2+)-binding sites inactive. In all tissues and cells studied, p11 is found in a heterotetrameric complex with another Ca(2+)-binding protein, annexin II (ANX2, LIP2). Furthermore, overexpression of P11 suppresses apoptosis induced by BAD , suggesting that P11 may be one of the intracellular signal molecules interacting with the Bcl-2 family of proteins to control apoptosis.

NCBI Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis.
General function Intracellular signaling cascade
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function Follicle atresia
Comment Chun et al 2001 reported the expression of messenger ribonucleic acid for the antiapoptosis gene p11 in the rat ovary and its stimulation by gonadotropins in granulosa cells of preovulatory follicles. P11, a member of the S100 family of calcium-binding proteins, has been shown to interact with BAD (Bcl-xL/Bcl-2-associated death promoter) in the yeast two-hybrid protein-protein interaction assay. Because overexpression of P11 dampens the proapoptotic activity of BAD in transfected cells, the authors tested the possibility that the expression of this antiapoptotic protein may be regulated by gonadotropins and other survival factors in the ovary. Northern blot analysis of ovaries obtained from prepubertal rats revealed an increased expression of P11 messenger RNA (mRNA) during prepubertal development in the theca cells of preantral and early antral follicles. Treatment of immature rats with PMSG did not affect P11 expression, whereas treatment of PMSG-primed rats with an ovulatory dose of human (h)CG stimulated ovarian P11 mRNA within 6-9 h in the granulosa cells of preovulatory follicles. Treatment with other follicle survival factors, including the epidermal growth factor, the basic fibroblast growth factor, and interleukin-1beta, could also stimulate P11 expression in cultured preovulatory follicles.
Expression regulated by FSH, LH, Growth Factors/ cytokines
Comment
Ovarian localization Granulosa, Theca
Comment
Follicle stages Primary, Secondary, Antral, Preovulatory
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
None
Search for Antibody


created: May 28, 2001, 4:04 p.m. by: hsueh   email:
home page:
last update: Aug. 14, 2001, 8:55 a.m. by: hsueh    email:



Use the back button of your browser to return to the Gene List.

Click here to return to gene search form