| Aldo-keto Reductase Family 1, Member C4 | OKDB#: 1197 |
| Symbols: | AKR1C4 | Species: | human | ||
| Synonyms: | C11, CDR, DD4, CHDR, HAKRA, MGC22581, 3-alpha-HSD,CHLORDECONE REDUCTASE, CHDR, CDR|ALDO-KETO REDUCTASE A, HAKRA|DIHYDRODIOL DEHYDROGENASE 4, DD4|3-@ALPHA-HYDROXYSTEROID DEHYDROGENASE, TYPE I | Locus: | 10p15-p14 in Homo sapiens |
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| General Comment |
Espey LL, et al 2001 reported 3 alpha-Hydroxysteroid Dehydrogenase Messenger RNA
Transcription in the Immature Rat Ovary in Response to an
Ovulatory Dose of Gonadotropin.
The ovulatory process in mammals involves a substantial increase in the
metabolism of steroids and eicosanoids in response to a surge in LH or to an
injection of hCG into experimental animals. This study provides evidence that
the ovulatory stimulus causes induction of the gene for 3alpha-hydroxysteroid
dehydrogenase (3alpha-HSD), an enzyme that belongs to several
oxidoreductase superfamilies that affect steroid and eicosanoid metabolism.
Immature Wistar rats were primed with 10 IU eCG s.c., and 48 h later the
12-h ovulatory process was initiated by 10 IU hCG s.c. Ovarian RNA was
extracted at 0, 2, 4, 8, 12, and 24 h after injecting the animals with hCG. The
RNA extracts were used for reverse transcription-polymerase chain reaction
(PCR) differential display to detect gene expression in the stimulated ovarian
tissue. One of the PCR primer sets differentially amplified a cDNA fragment
that is 52.3% homologous with a 3alpha-HSD gene in rat liver. Northern
analyses revealed that maximum transcription was at 8 h after the animals had
been treated with hCG. The Northerns also indicated that the 3alpha-HSD
cDNA probe cross-hybridized with as many as six different bands of mRNA
on the blots. In situ hybridization localized 3alpha-HSD mRNA in the
granulosa and thecal layers of mature follicles and in newly formed corpora
lutea at 24 h after the ovulatory stimulus. In conclusion, gene(s) for
3alpha-HSD are transcribed in ovarian follicles in response to an ovulatory
dose of gonadotropin. A possible function of the oxidoreductase enzyme that
is translated from the 3alpha-HSD mRNA may be to reduce the toxic
aldehyde and ketone components of the steroids and eicosanoids that
accumulate in the mammalian ovary at the time of ovulation.
NCBI Summary: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq] |
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| General function | Enzyme, Oxidoreductase | ||||
| Comment | |||||
| Cellular localization | Cytoplasmic | ||||
| Comment | |||||
| Ovarian function | Ovulation, Steroid metabolism | ||||
| Comment | |||||
| Expression regulated by | LH | ||||
| Comment | |||||
| Ovarian localization | Granulosa, Theca, Luteal cells | ||||
| Comment | |||||
| Follicle stages | Preovulatory, Corpus luteum | ||||
| Comment | |||||
| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | June 24, 2001, 10:22 a.m. | by: |
hsueh email:
home page: |
| last update: | March 3, 2009, 10:15 a.m. | by: | hsueh email: |
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