| Kallikrein 8 | OKDB#: 1221 |
| Symbols: | KLK8 | Species: | human | ||
| Synonyms: | NEUROPSIN, MOUSE, HOMOLOG OF| TUMOR-ASSOCIATED DIFFERENTIALLY EXPRESSED GENE 14, TADG14| PROTEASE, SERINE, 19, PRSS19| NEUROPSIN, MOUSE, HOMOLOG OF, TYPE 1, INCLUDED| NEUROPSIN, MOUSE, HOMOLOG OF, TYPE 2, INCLUDED| | Locus: | 19q13.4 in Homo sapiens |
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| General Comment |
Tissue kallikrein is a serine protease thought to be involved in the generation of bioactive peptide kinins from kininogen in many organs such as
the kidneys, colon, salivary glands, pancreas, and blood vessels. Unlike pepsin, members of the glandular kallikrein subfamily of
serine proteases demonstrate a high degree of substrate specificity. The true physiologic role of specific kallikreins is often unrelated to the kininogenase activity.
NCBI Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer. |
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| General function | Enzyme, Hydrolase, Peptidase/Protease | ||||
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| Cellular localization | Secreted | ||||
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| Ovarian function | Ovulation | ||||
| Comment | Holland AM, et al reported kallikrein gene expression in the gonadotrophin-stimulated rat ovary. . The kallikreins (KLKs) are a highly conserved multi-gene family of serine proteases that are expressed in a wide variety of tissues and act on a diverse range of substrates. KLK-like enzyme activity has variously been reported to increase or decrease during the period leading up to ovulation in the equine chorionic gonadotrophin (eCG)primed, human chorionic gonadotrophin (hCG)-stimulated immature rat ovary. They used a gene-specific RT-PCR/Southern hybridisation strategy to delineate the expression patterns of six of the individual KLK genes expressed in the rat ovary (rKLK1-3 and rKLK7-9) and have identified three broad patterns of expression in the eCG/hCG-stimulated ovary in which there is either a post-eCG increase/pre-ovulatory decrease in rKLK expression (rKLK1, rKLK3), a peri-ovulatory decrease in expression (rKLK2, rKLK8) or a relatively unchanged pattern of expression (rKLK7, rKLK9). In addition to clarifying the earlier biochemical studies, these findings support a differential role for the individual KLKs in the ovulatory process. | ||||
| Expression regulated by | LH | ||||
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| Ovarian localization | |||||
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| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | July 3, 2001, 9:08 p.m. | by: |
hsueh email:
home page: |
| last update: | Aug. 13, 2001, 3:45 p.m. | by: | hsueh email: |
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