Based on the biochemical, immunologic, and structural properties of Glutathione
S-transferase superfamily members, the soluble human GSTs are categorized into 4
main classes: alpha, mu, pi, and theta.
General function
Enzyme, Transferase
Comment
Cellular localization
Cytoplasmic
Comment
Ovarian function
Steroid metabolism, Luteinization
Comment
Carlos Stocco, et al 2001 reported
opposite Effect of Prolactin and Prostaglandin F2 on the Expression of Luteal Genes as Revealed by Rat
cDNA Expression Array.
It is well established that prolactin (PRL) sustains, while prostaglandin F2 (PGF2) curtails, progesterone production
by the rat corpus luteum (CL). In this investigation, the authors found twelve more
genes that are inversely regulated by PRL and PGF2. In addition to 20-HSD, PGF2 stimulated and PRL inhibited
PGF2-receptor, phospholipase C1 and TGF1 expression. In contrast PRL stimulated and PGF2 inhibited the LH
receptor, 11-HSD2, sterol carrier protein 2, mitochondrial glutathione S-transferase (GST), GST2, inhibitory DNA-binding proteins 1, 2, and 3, and calcium binding protein 2.