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General Comment |
The functional sodium channel, channel is composed of at least 3 subunits, alpha (OMIM 600228), beta, and gamma (OMIM 600761). The 3 subunits
show sequence similarities to one another, indicating descent from a common ancestral gene. Each encodes a protein
containing 2 transmembrane domains, with intracellular amino and carboxyl termini.
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Comment |
Carlos Stocco, et al 2001 reported
opposite Effect of Prolactin and Prostaglandin F2 on the Expression of Luteal Genes as Revealed by Rat
cDNA Expression Array.
It is well established that prolactin (PRL) sustains, while prostaglandin F2 (PGF2) curtails, progesterone production
by the rat corpus luteum (CL). In this investigation, the authors found twelve more
genes that are inversely regulated by PRL and PGF2. In addition to 20-HSD, PGF2 stimulated and PRL inhibited
PGF2-receptor, phospholipase C1 and TGF1 expression. In contrast PRL stimulated and PGF2 inhibited the LH
receptor, 11-HSD2, sterol carrier protein 2, mitochondrial glutathione S-transferase (GST), GST2, inhibitory DNA-binding proteins 1, 2, and 3, and calcium binding protein 2. PGF2 stimulated the expression of genes involved in cell signaling such as
cell adhesion kinase-, ERK3, FRA2, IL-2 receptor, and 14-3-3 proteins. PGF2 also up-regulated the expression of the sodium channel 1, Na/K ATPase, annexin IV, GST7, and P450 reductase.
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