Pancreatic secretory trypsin inhibitor is secreted from pancreatic acinar cells into pancreatic juice. Its physiologic role
has been thought to be the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the
pancreatic duct. Since it is also found in serum and in various normal and malignant tissues, it may have other roles as
well.
General function
Cell death/survival, Anti-apoptotic
Comment
Cellular localization
Secreted
Comment
Ovarian function
Oogenesis, Oocyte maturation
Comment
Gene whose expression is detected by cDNA array hybridization: stress response, cell/cell communication. Also, relative transcript level reproducibly decreases during IVM Rozenn Dalbis-Tran and Pascal Mermilloda
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Antral, Preovulatory
Comment
Liu HC, et al 2001 reported tha application of complementary DNA microarray (DNA chip) technology in the study of gene expression profiles during
folliculogenesis.
They used oligonucleotide microarray (DNA chip)-based hybridization
analysis to gain a comprehensive view of gene expression and regulation
involved in folliculogenesis.
Preantral follicles isolated from day 14 B6D2F-1 mice
were stimulated in vitro to form Graafian follicles. Total RNA extracted from
the mouse preantral and Graafian follicles were reverse transcribed, labeled
with digoxigenin-11-dUTP, and then hybridized with Clontech Atlas mouse cDNA
expression arrays for comparison. Of 588 known studied genes, 39 and 61 were detected in preantral follicles and in Graafian follicles, respectively, and 17 were highly
expressed consistently in both preantral and Graafian follicles, including SERINE PROTEASE INHIBITOR, KAZAL-TYPE, 2; SPINK2.