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PROTEINASE 3; PRTN3 OKDB#: 1282
 Symbols: PROTEINASE 3; PRTN3 Species: human
 Synonyms: PR3| MYELOBLASTIN, MBT| WEGENER AUTOANTIGEN, P29| AZUROPHIL GRANULE PROTEIN 7, AGP7| SERINE PROTEINASE, NEUTROPHIL|  Locus: 19p13.3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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R-L INTERACTIONS   MGI

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General Comment Proteinase-3 is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family. It is closely related to 2 others: neutrophil elastase (ELA2; OMIM 130130) and azurocidin (AZU; OMIM 162815).

General function Enzyme, Peptidase/Protease
Comment
Cellular localization Secreted
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages Antral, Preovulatory
Comment Liu HC, et al 2001 reported tha application of complementary DNA microarray (DNA chip) technology in the study of gene expression profiles during folliculogenesis. They used oligonucleotide microarray (DNA chip)-based hybridization analysis to gain a comprehensive view of gene expression and regulation involved in folliculogenesis. Preantral follicles isolated from day 14 B6D2F-1 mice were stimulated in vitro to form Graafian follicles. Total RNA extracted from the mouse preantral and Graafian follicles were reverse transcribed, labeled with digoxigenin-11-dUTP, and then hybridized with Clontech Atlas mouse cDNA expression arrays for comparison. Of 588 known studied genes, 39 and 61 were detected in preantral follicles and in Graafian follicles, respectively, and 17 were highly expressed consistently in both preantral and Graafian follicles. Performing clustering analysis, 15 detected genes were down-regulated and 46 were upregulated as the follicles advanced to mature stages. The Proteinase gene is down-regulated in the Graafian follicles.
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
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created: Sept. 10, 2001, 3:13 p.m. by: hsueh   email:
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last update: Sept. 10, 2001, 3:13 p.m. by: system    email:



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