The lymphokine IL-2 affects the growth and differentiation of T cells, B cells, natural killer cells, glioma cells, and
cells of the monocyte lineage after specifically interacting with its receptors. IL2R exists in different isoforms made up
of alpha (OMIM 147730) and beta (OMIM 146710) subunits. Takeshita et al. (1992) identified a third subunit, the gamma chain, and
isolated a cDNA encoding this protein. They showed that the gamma chain is necessary for the formation of the high-
and intermediate-affinity receptors, which consist of alpha-beta-gamma heterotrimers and beta-gamma heterodimers,
respectively.
NCBI Summary:
The interleukin 2 (IL2) receptor gamma chain (IL2RG), an important signalling component of many interleukin receptors (IL2,IL4,IL7,IL9, and IL15), is thus referred to as the common gamma chain. Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID).
General function
Receptor
Comment
Cellular localization
Plasma membrane
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Ovarian function
Comment
Expression regulated by
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Ovarian localization
Comment
Follicle stages
Antral, Preovulatory
Comment
Liu HC, et al 2001 reported tha application of complementary DNA microarray (DNA chip) technology in the study of gene expression profiles during
folliculogenesis.
They used oligonucleotide microarray (DNA chip)-based hybridization
analysis to gain a comprehensive view of gene expression and regulation
involved in folliculogenesis.
Preantral follicles isolated from day 14 B6D2F-1 mice
were stimulated in vitro to form Graafian follicles. Total RNA extracted from
the mouse preantral and Graafian follicles were reverse transcribed, labeled
with digoxigenin-11-dUTP, and then hybridized with Clontech Atlas mouse cDNA
expression arrays for comparison. Of 588 known studied genes, 39 and 61 were detected in preantral follicles and in Graafian follicles, respectively, and 17 were highly
expressed consistently in both preantral and Graafian follicles. Performing
clustering analysis, 46 were upregulated as the follicles advanced to mature stages.
The INTERLEUKIN 2 RECEPTOR, GAMMA gene is up-regulated in the Graafian follicles.