| Taf4 Rna Polymerase Ii, Tata Box-binding Protein-associated Factor, 135-kd | OKDB#: 1317 |
| Symbols: | TAF4 | Species: | human | ||
| Synonyms: | TAF2C, TAF4A, TAF2C1, FLJ41943, TAFII130, TAFII135,TAF4A RNA POLYMERASE II, TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR, 135-KD, TAF4A|TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR C1, TAF2C1|TAF2C|TBP-ASSOCIATED FACTOR, RNA POLYMERASE II, 130-KD, TAFII130|TA | Locus: | 20q13.33 in Homo sapiens |
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| General Comment |
Transcription factor TFIID is a multiprotein complex composed of the TATA box-binding protein (TBP; OMIM 600075) and
multiple TBP-associated factors (TAFs; see 313650). Tanese et al. (1996) cloned cDNAs encoding 2 subunits of the
human TFIID complex: TAFII130 (also symbolized TAF2C1) and TAFII100.
NCBI Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq] |
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| General function | DNA binding, Transcription factor | ||||
| Comment | |||||
| Cellular localization | Nuclear | ||||
| Comment | |||||
| Ovarian function | Follicle development | ||||
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| Expression regulated by | |||||
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| Ovarian localization | Oocyte, Granulosa, Luteal cells | ||||
| Comment | Freiman et al. (2001) reported that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary. They also found TAF II 130 expression in oocyte, granulosa and luteal cells. Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAFII105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient ovaries. These studies suggest that TAFII105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAFII105 as a cell type-specific component of the mammalian transcriptional machinery. | ||||
| Follicle stages | |||||
| Comment | oxyz | ||||
| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Oct. 1, 2001, 11:51 a.m. | by: |
hsueh email:
home page: |
| last update: | April 1, 2010, 10:32 a.m. | by: | hsueh email: |
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