Autocrine motility factor (AMF; 172400) is a protein secreted by tumor cells that stimulates tumor motility. Its receptor
is a 78-kD glycoprotein (gp78).
NCBI Summary:
Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells. [provided by RefSeq]
General function
Receptor
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Cellular localization
Plasma membrane
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Ovarian function
Oogenesis
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Expression regulated by
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Ovarian localization
Oocyte
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J.L. Stanton et al 2001 reported a set of 840 mouse oocyte genes with well-matched
human homologues. The autocrine motility factor receptor was found in the mouse oocyte.
GenBank contains 14 477 expressed sequence tags (EST) derived from mouse oocyte cDNA libraries: 3499 of these
are from two unfertilized oocyte libraries and 10 978 are from two fertilized oocyte libraries. Gene expression profiles
were obtained for these libraries by matching library EST to UniGene clusters. The 14 477 EST identified 4226
UniGenes. These were screened using HomoloGene to identify 1386 homologous UniGene clusters in two other species
with one of the matches being human. Within these human matches, 840 encoded named proteins, 223 encoded
hypothetical proteins, and 323 encoded clustered EST. The set of named genes provides the first step in establishing a
database of genes expressed in mouse oocytes and, by extension, human oocytes.