| G PROTEIN-COUPLED RECEPTOR 56 | OKDB#: 1356 |
| Symbols: | GPR56 | Species: | human | ||
| Synonyms: | 7-@TRANSMEMBRANE PROTEIN WITH NO EGF-LIKE N-TERMINAL DOMAINS 1, TM7XN1| | Locus: | 16q13 in Homo sapiens | HPMR |
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| General Comment |
By PCR of human cDNAs with degenerate primers based on
conserved regions from secretin-like receptors, a cDNA encoding a novel receptor, GPR56, was isolated. The predicted 693-amino acid GPR56 protein shares 26 to 32% sequence identity with the 4
class B-like orphan receptors. Like these receptors, GPR56 contains 7 transmembrane domains as well as a mucin-like
domain and cysteine box in the N-terminal region. Northern blot analysis revealed that the GPR56 gene was expressed
as a 3-kb mRNA in a wide range of tissues, with the highest levels in thyroid.
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| General function | Receptor | ||||
| Comment | |||||
| Cellular localization | Plasma membrane | ||||
| Comment | |||||
| Ovarian function | Oogenesis | ||||
| Comment | |||||
| Expression regulated by | |||||
| Comment | |||||
| Ovarian localization | Oocyte | ||||
| Comment | J.L. Stanton et al 2001 reported a set of 840 mouse oocyte genes with well-matched human homologues. The GPR56 was found in the mouse oocyte EST. | ||||
| Follicle stages | |||||
| Comment | zyxw | ||||
| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Nov. 1, 2001, 12:54 p.m. | by: |
hsueh email:
home page: |
| last update: | Feb. 20, 2010, 5:47 p.m. | by: | hsueh email: |
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