| G Protein-coupled Receptor 85 | OKDB#: 1357 |
| Symbols: | GPR85 | Species: | mouse | ||
| Synonyms: | SUPERCONSERVED RECEPTOR EXPRESSED IN BRAIN 2, SREB2 | Locus: | 7q31 in Homo sapiens |
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| General Comment |
The predicted 370-amino
acid SREB2 protein contains several features of the GPCR family, including 7 transmembrane domains, potential
N-linked glycosylation sites in the N-terminal extracellular domain, and conserved cysteine residues, which may form a
disulfide bridge, in the first and second extracellular loops. However, SREB2 shares additional characteristics with
SREB1 and SREB3 (300253) that are not also shared with other GPCRs, including identical amino acid substitutions of
residues conserved in other GPCRs, an absence of prolines in the fifth transmembrane domain, and a relatively large
conserved third cytoplasmic loop that has no sequence similarity to the third cytoplasmic loops of other GPCRs. High levels of SREB2
expression were found in brain and testis. This is an orphan receptor.
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| General function | Receptor | ||||
| Comment | |||||
| Cellular localization | Plasma membrane | ||||
| Comment | |||||
| Ovarian function | Oogenesis | ||||
| Comment | |||||
| Expression regulated by | |||||
| Comment | |||||
| Ovarian localization | Oocyte | ||||
| Comment | J.L. Stanton et al 2001 reported a set of 840 mouse oocyte genes with well-matched human homologues. The GPR85 was found in the mouse oocyte EST. | ||||
| Follicle stages | |||||
| Comment | |||||
| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Nov. 1, 2001, 12:59 p.m. | by: |
hsueh email:
home page: |
| last update: | Aug. 6, 2005, 11:17 a.m. | by: | system email: |
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