Stanford Home
Ovarian Kaleidoscope Database (OKdb)

Home

History

Transgenic Mouse Models

INFORGRAPHICS

Search
Submit
Update
Chroms
Browse
Admin

Hsueh lab

HPMR

Visits
since 01/2001:
176557

G Protein-coupled Receptor 85 OKDB#: 1357
 Symbols: GPR85 Species: mouse
 Synonyms: SUPERCONSERVED RECEPTOR EXPRESSED IN BRAIN 2, SREB2  Locus: 7q31 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
Mammalian Reproductive Genetics   Endometrium Database Resource   Orthologous Genes   UCSC Genome Browser   GEO Profiles new!   Amazonia (transcriptome data) new!

R-L INTERACTIONS   MGI

DNA Microarrays
SHOW DATA ...
link to BioGPS
General Comment The predicted 370-amino acid SREB2 protein contains several features of the GPCR family, including 7 transmembrane domains, potential N-linked glycosylation sites in the N-terminal extracellular domain, and conserved cysteine residues, which may form a disulfide bridge, in the first and second extracellular loops. However, SREB2 shares additional characteristics with SREB1 and SREB3 (300253) that are not also shared with other GPCRs, including identical amino acid substitutions of residues conserved in other GPCRs, an absence of prolines in the fifth transmembrane domain, and a relatively large conserved third cytoplasmic loop that has no sequence similarity to the third cytoplasmic loops of other GPCRs. High levels of SREB2 expression were found in brain and testis. This is an orphan receptor.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Oogenesis
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment J.L. Stanton et al 2001 reported a set of 840 mouse oocyte genes with well-matched human homologues. The GPR85 was found in the mouse oocyte EST.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
None
Search for Antibody


created: Nov. 1, 2001, 12:59 p.m. by: hsueh   email:
home page:
last update: Aug. 6, 2005, 11:17 a.m. by: system    email:



Use the back button of your browser to return to the Gene List.

Click here to return to gene search form