Two 2 ERBA-related genes, named EAR2 and EAR3 , are predicted to encode proteins very similar in primary structure to
receptors for steroid hormones and thyroid hormone. In addition, the amino acid sequences of the 2 gene products are
very similar to each other, especially in the DNA-binding domain (86% homology) and at the putative ligand-binding
domain (76% homology).
General function
DNA binding, Transcription factor
Comment
Cellular localization
Nuclear
Comment
Ovarian function
Ovulation, Luteinization
Comment
Expression regulated by
Comment
Ovarian localization
Granulosa
Comment
Ying Zhang
and Maria L. Dufau 2001 reported that EAR2 and EAR3/COUP-TFI Regulate Transcription
of the Rat LH Receptor.
hCG treatment significantly reduced the inhibition of LHR gene in granulosa cells and also decreased EAR2 and EAR3/COUP-TFI protein levels. These results indicate that hormonally regulated expression of EAR2 and EAR3/COUP-TFI contributes to gonadotropin-induced derepression of LHR promoter activity in granulosa cells.