Tissue kallikrein is a serine protease thought to be involved in the generation of
bioactive peptide kinins from kininogen in many organs such as the kidneys, colon,
salivary glands, pancreas, and blood vessels. Unlike pepsin, members of the
glandular kallikrein subfamily of serine proteases demonstrate a high degree of
substrate specificity. The true physiologic role of specific kallikreins is often
unrelated to the kininogenase activity.
General function
Enzyme, Peptidase/Protease
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Cellular localization
Secreted
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Ovarian function
Follicle development
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Expression regulated by
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Ovarian localization
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Follicle stages
Primordial
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Petraki CD, et al 2001 reported the spectrum of human kallikrein 6 (zyme/protease M/neurosin)
expression in human tissues as assessed by immunohistochemistry.
The KLK6 gene is anew member of the human kallikrein gene family and encodes
for a secreted protease, human kallikrein 6 (hK6; also known as zyme/protease
M/neurosin). Immunohistochemistry staining
Indicated expression of KLK6 was generally cytoplasmic.
A characteristic immunostaining was observed
in the primordial follicles of the ovary.