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General Comment |
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell
trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors.
Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have
effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved
cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.
Marchese et al. (1994) cloned a gene with the 7 transmembrane domains characteristic of G protein-coupled receptors.
NCBI Summary:
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM]
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Comment |
Northern blot analysis by Jarmin et al. (2000) detected high-level expression of a 1.4-kb GPR2 transcript in adult testis
and small intestine and fetal lung and kidney. Weaker expression was detected in adult spleen, thymus, lymph node, colon,
heart, ovary, peripheral blood leukocytes, and spinal cord.
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