VOLTAGE-GATED CHLORIDE CHANNEL. CHLORIDE CHANNELS HAVE
SEVERAL FUNCTIONS INCLUDING THE REGULATION OF CELL VOLUME; MEMBRANE
POTENTIAL STABILIZATION, SIGNAL TRANSDUCTION AND TRANSEPITHELIAL
TRANSPORT.
NCBI Summary:
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.
General function
Channel/transport protein
Comment
Cellular localization
Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
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Ovarian localization
Comment
EXPRESSED PROLIFE: Testis, ovary, small intestine, brain and
skeletal muscle. Low level expression in aortic and coronary
vascular smooth muscle cells, and aortic endothelial cells. Isoform
C is only detected in kidney.