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CADHERIN 6; CDH6 OKDB#: 1424
 Symbols: CADHERIN 6; CDH6 Species: human
 Synonyms: CADHERIN, FETAL KIDNEY| K-CADHERIN|  Locus: 5p15.1-p14 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment Cadherins are calcium-dependent cell-cell adhesion molecules that mediate cell-cell binding in a homophilic manner. They play key roles in morphogenesis and in the maintenance of orderly structures such as epithelium, and may be involved in the metastasis and invasion of cancer. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the homophilic cell adhesion activity of the cadherin; the amino acid sequence of the cytoplasmic domain is highly conserved among cadherins.

NCBI Summary: This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.
General function Cell adhesion molecule
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Follicle development
Comment
Expression regulated by
Comment
Ovarian localization Granulosa, Theca, Stromal cells, Surface epithelium
Comment Machell NH, et al 2002 reported the expression and localization of P-, K-, and OB-cadherin in the prepubertal rat ovary. Classical and atypical cadherins mediate calcium-dependent cell adhesion and play an important role in morphogenetic processes. In this study, RT-PCR and immunostaining techniques showed that three cadherins are expressed throughout prepubertal ovarian development in the rat: one classical (P-) cadherin, and two atypical (K- and OB-) cadherins. RT-PCR analysis of isolated ovarian tissue compartments (granulosa cells and the residual ovarian tissue) agreed with the immunostaining results. Immunostaining showed P- and K-cadherin expression by granulosa, as well as thecal/interstitial cells, and also in oocytes of primordial follicles. P-cadherin expression was absent in oocytes of follicles in later stages of development compared to K-cadherin, which was found in oocytes at all stages of folliculogenesis. P-, K-, and OB-cadherin were expressed by the ovarian surface epithelial cells of neonatal animals but only P- and OB-cadherin expression were maintained in these cells in 25 day-old animals. Cellular OB-cadherin staining was absent in follicles at all stages of development and its expression was restricted to the ovarian hilar region and portions of the stroma. In summary, cadherin expression and distribution profiles changed during ovarian growth and folliculogenesis suggesting a role for cadherins in organizational and morphogenetic processes within the developing rat ovary.
Follicle stages Primordial, Primary, Secondary, Antral, Preovulatory
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Jan. 29, 2002, 7:23 p.m. by: hsueh   email:
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last update: Jan. 29, 2002, 7:23 p.m. by: system    email:



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