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Ovarian Kaleidoscope Database (OKdb)

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GATA-BINDING PROTEIN 2; GATA2 OKDB#: 1426
 Symbols: GATA-BINDING PROTEIN 2; GATA2 Species: human
 Synonyms:  Locus: 3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells.

General function DNA binding, Transcription factor
Comment
Cellular localization Nuclear
Comment
Ovarian function Germ cell development
Comment
Expression regulated by
Comment
Ovarian localization Primordial Germ Cell
Comment Siggers P, et al 2002 reported sexually dimorphic expression of Gata-2 during mouse gonad development. Gata-2 transcripts accumulate rapidly in the fetal ovary from 11.5 days post coitum (dpc) onwards, but are not detected in the fetal testis throughout the period studied (10.5-15.5 dpc). Ovarian expression of Gata-2 ceases by 15.5 dpc. Examination of ovaries from embryos homozygous for the extreme allele of c-kit(W(e)) (Nature, 335, 88; Cell, 55, 185) demonstrates that ovarian Gata-2 expression is dependent upon the presence of germ cells. Comparative in situ hybridisation using the germ cell marker Oct4 (EMBO J., 8, 2543) indicates that Gata-2 transcripts are restricted to the germ cell lineage at 13.5 dpc.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Feb. 1, 2002, 8:32 p.m. by: hsueh   email:
home page:
last update: Feb. 1, 2002, 8:32 p.m. by: system    email:



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