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POTASSIUM CHANNEL, VOLTAGE-GATED, SHAKER-RELATED SUBFAMILY,MEMBER 1; KCNA1 OKDB#: 1437
 Symbols: POTASSIUM CHANNEL, VOLTAGE-GATED, SHAKER-RELATED S Species: human
 Synonyms: MK1, MOUSE, HOMOLOG OF| KV1.1|  Locus: 12p13 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment Potassium ion channels are essential to many cellular functions in both excitable and nonexcitable cells and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties.

General function Channel/transport protein
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Oogenesis, Oocyte maturation
Comment Gene whose expression is detected by cDNA array hybridization: oncogenes, tumor suppressors, cell cycle regulators Rozenn Dalbis-Tran and Pascal Mermilloda
Expression regulated by
Comment
Ovarian localization Granulosa
Comment Mason DE, et al 2002 reported the molecular basis of voltage-dependent potassium currents in porcine granulosa cells. The major objective of this study was to elucidate the molecular bases for K+ current diversity in porcine granulosa cells (GC). Two delayed rectifier K+ currents with distinct electrophysiological and pharmacological properties were recorded from porcine GC by using whole-cell patch clamp: 1) a slowly activating, noninactivating current (I-Ks) antagonized by clofilium, 293B, L-735,821, and L-768,673; and 2) an ultrarapidly activating, slowly inactivating current (I-Kur) antagonized completely by clofilium and 4-aminopyridine and partially by tetraethylammonium, charybdotoxin, dendrotoxin, and kaliotoxin. The molecular identity of the K+ channel genes underlying I-Ks and I-Kur was examined using reverse transcription-polymerase chain reaction and immunoblotting to detect K+ channel transcripts and proteins. It was found that GC could express multiple voltage-dependent K+ (Kv) channel subunits, including KCNQ1, KCNE1, Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6, Kvbeta1.3, and Kvbeta2. Coimmunoprecipitation was used to establish the hetero-oligomeric nature of granulosa cell Kv channels. KCNE1 and KCNQ1 were coassociated in GC, and their expression coincided with the expression of I-Ks. Extensive coassociation of the various Kv alpha- and beta-subunits was also documented, suggesting that the diverse electrophysiological and pharmacological properties of I-Kur currents may reflect variation in the composition and stoichiometry of the channel assemblies, as well as differences in post-translational modification of contributing Kv channel subunits. These findings provide an essential background for experimental definition of granulosa K+ channel function(s). It will be critical to define the functional roles of specific GC K+ channels, because these proteins may represent either novel targets for assisted reproduction or potential sites of drug toxicity.
Follicle stages Antral
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Feb. 13, 2002, 2:02 p.m. by: hsueh   email:
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last update: July 25, 2006, 2:57 p.m. by: Alex    email:



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