| RFP 14; Ret finger like gene family 14 | OKDB#: 1454 |
| Symbols: | RFP 14; Ret finger like gene family 14 | Species: | human | ||
| Synonyms: | Locus: |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
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Amazonia (transcriptome data)
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R-L INTERACTIONS MGI |
| General Comment |
Rajkovic A, et al 2002 reported that the ret finger protein-like 4 gene, Rfpl4, encodes a putative E3
ubiquitin-protein ligase expressed in adult germ cells.
Using an in silico (electronic database) subtraction, the authors identified a new member of
the Ret Finger Protein-Like gene family, Rfpl4. Rfpl4 encodes a 287 amino acid
putative E3 ubiquitin-protein ligase with a RING finger-like domain and a B30.2
motif. Reverse transcriptase polymerase chain reaction and Northern blot analyses
reveal that Rfpl4 encodes a 1.7kb mRNA detectable exclusively in the gonads of adult
mice. In situ hybridization localizes Rfpl4 transcripts within the ovary to oocytes of
primary and later stage follicles and in the testis to elongating spermatids. The Rfpl4
gene comprises three exons and maps to mouse chromosome 7. The
human ortholog maps to 19q13.4. These studies suggest that RFPL4 mediates
protein degradation pathways important for gametogenesis or early embryonic
development.
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| General function | DNA binding, Transcription factor | |||
| Comment | ||||
| Cellular localization | Nuclear | |||
| Comment | ||||
| Ovarian function | Oogenesis | |||
| Comment | ||||
| Expression regulated by | ||||
| Comment | ||||
| Ovarian localization | Oocyte | |||
| Comment | ||||
| Follicle stages | Secondary, Antral | |||
| Comment | ||||
| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
| Links |
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| created: | March 7, 2002, 4:42 p.m. | by: |
hsueh email:
home page: |
| last update: | March 7, 2002, 4:42 p.m. | by: | system email: |
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