| Plexin B2 | OKDB#: 1480 |
| Symbols: | PLXNB2 | Species: | human | ||
| Synonyms: | MM1| | Locus: | 22q13.31-q13.33 in Homo sapiens | HPMR |
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| General Comment |
Plexins are a large family of receptors for transmembrane, secreted, and
GPI-anchored semaphorins in vertebrates Tamagnone L, et al
In Drosophila, plexin A is a functional receptor for semaphorin-1a. The human
plexin gene family comprises at least nine members in four subfamilies. Plexin-B1 is a receptor for
the transmembrane semaphorin Sema4D (CD100), and plexin-C1 is a receptor for the GPI-anchored
semaphorin Sema7A (Sema-K1). Secreted (class 3) semaphorins do not bind directly to plexins, but
rather plexins associate with neuropilins, coreceptors for these semaphorins. Plexins are widely
expressed: in neurons, the expression of a truncated plexin-A1 protein blocks axon repulsion by
Sema3A. The cytoplasmic domain of plexins associates with a tyrosine kinase activity. Plexins may
also act as ligands mediating repulsion in epithelial cells in vitro. Plexins are
receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with
neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion.
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| General function | Receptor | ||||
| Comment | |||||
| Cellular localization | Plasma membrane | ||||
| Comment | |||||
| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | |||||
| Comment | Found in ovarian cDNA library. | ||||
| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | April 10, 2002, 3:55 p.m. | by: |
hsueh email:
home page: |
| last update: | April 10, 2002, 3:55 p.m. | by: | system email: |
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