Many growth factors and hormones modulate the reproductive status in mammals.
Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development
of gonadal tissues. SH2-B has been shown to interact with insulin and IGF-I
receptors, although the role of SH2-B in these signals has not been clarified. SH2-B is downstream of the IGF receptor pathway and was originally identified by using a yeast trihybrid system as a protein associated with an immunoreceptor
tyrosine-based activation motif in the high-affinity immunoglobulin E (IgE) receptor Fc-RI. SH2-B contains a
proline-rich domain, a Pleckstrin homology (PH) domain, and an SH2 domain.
General function
Comment
Cellular localization
Cytoplasmic
Comment
Ovarian function
Follicle development, Cumulus expansion
Comment
Expression regulated by
Comment
Ovarian localization
Cumulus, Stromal cells
Comment
Immunohistochemically stained gonadal tissues (testis and ovary) from
wild-type mice indicated that SH2-B was localized in Leydig cells of the testis and stromal cells of the ovary. Ohtsuka S et al 2002
Follicle stages
Antral, Preovulatory
Comment
Phenotypes
Mutations
1 mutations
Species: mouse
Mutation name: None
type: null mutation fertility: infertile - ovarian defect Comment:Ohtsuka S et al 2002 reported that
SH2-B Is Required for Both Male and Female Reproduction.
Both male and female SH2-B(-/-) mice showed slight retardation in
growth and impaired fertility. Female knockout mice possess small, anovulatory
ovaries with reduced numbers of follicles and male SH2-B(-/-) mice have small
testes with a reduced number of sperm. SH2-B(-/-) cumulus cells do not respond to
either follicle-stimulating hormone or IGF-I. These data suggest that SH2-B plays a
critical role in the IGF-I-mediated reproductive pathway in mice.