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General Comment |
Wicki et al. (1996) reported the characterization of a human gene they symbolized S100A13, a calcium-binding protein
belonging to the S100 protein family. S100 proteins are small EF-hand calcium-binding proteins of variable lengths and
sequence identities. At least 12 of 15 members of the family are clustered on chromosome 1q21 (see S100A1; OMIM 176940);
S100A13 likewise colocalizes with S100A1 on the 1q21 cluster. The predicted 98 amino acid S100A13 protein shows
sequence homologies to other S100 proteins between 50.5% (S100A5; 176991) and 59.3% (S100A12; 603112). Northern
blot analysis showed high amounts of S100A13 mRNA in adult skeletal muscle, heart, kidney, ovary, spleen, small intestine,
and pancreas and in fetal lung, heart, cochlea, liver, spleen, and parathyroid tumor cells.
NCBI Summary:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction.
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