| ELEVEN NINETEEN LYSINE-RICH LEUKEMIA GENE | OKDB#: 1498 |
| Symbols: | ELEVEN NINETEEN LYSINE-RICH LEUKEMIA GENE | Species: | human | ||
| Synonyms: | ELL| | Locus: | 19p13.1 in Homo sapiens |
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| General Comment |
By PCR screening of a cDNA library prepared from
a patient's leukemia cells with t(11;19)(q23;p13.1) translocation, Thirman et al. (1994) obtained a fusion transcript containing exon 7 of
MLL and sequence of an unknown gene. The sequence of this gene was amplified and used as a probe to screen a fetal brain
cDNA library. On Northern blot analysis, this cDNA detected a 4.4-kb transcript that was abundant in peripheral blood
leukocytes, skeletal muscle, placenta, and testis and expressed at lower levels in spleen, thymus, heart, brain, lung, kidney,
liver, and ovary. ELL encodes an elongation factor that can increase the catalytic rate of RNA
polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL is the second elongation factor to be implicated in oncogenesis,.
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| General function | Transcription factor | ||||
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| Cellular localization | |||||
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| Ovarian function | |||||
| Comment | Khattak S, et al 2002 reported dELL, a drosophila homologue of transcription elongation factor ELL (eleven-nineteen lysine rich leukemia), is required for early Development in fly. ELL (Eleven-nineteen Lysine rich Leukemia) is known to be an elongation factor resembling elongin for RNA polymerase II transcription. A homologue of human ELL (hELL) was identified in Drosophila melanogaster (dELL) and several cDNA clones were isolated from the embryonic cDNA library. dELL is expressed mainly in the ovaries and early embryonic stages by developmental Northern blot. dELL encodes a protein of 912 amino acids which is substantially longer than the hELL (612 aa). Immunostaining revealed that dELL was localized to nuclei in early embryos and to nuclei of nurse cells and follicle cells in the ovary suggesting its important role in early development of drosophila. To elucidate the function of this gene in drosophila, P-element mobilization was performed by utilizing a P-element inserted upstream of dELL. Southern analysis showed that isolated mutants are internal P-element deletions. These P-element deletions can now be used to isolate dELL mutations by EMS mutagenesis. | ||||
| Expression regulated by | |||||
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| Ovarian localization | |||||
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| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | May 4, 2002, 8:13 a.m. | by: |
hsueh email:
home page: |
| last update: | May 4, 2002, 8:13 a.m. | by: | system email: |
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