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Ovarian Kaleidoscope Database (OKdb)

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OBox3 OKDB#: 1504
 Symbols: OBox3 Species: mouse
 Synonyms:  Locus:


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General Comment Rajkovic A, et al 2002 reported that Obox represents a family of homeobox genes preferentially expressed in germ cells. The authors used in silico (electronic database) subtraction to identify ESTs that are preferentially expressed in the adult mouse germ cells. During the analysis, they identified Obox1 and Obox2 transcripts as preferentially expressed in the mouse unfertilized egg libraries. Obox1 and Obox2 transcripts encode homeodomain proteins of 204 amino acids that share 97% identity with each other. Further characterization of mouse BACs encoding Obox1 and Obox2, as well as available BAC and EST sequences in GenBank, identified four closely related genes: Obox3, Obox4, Obox5, and Obox6. Northern blot analyses and RT-PCR from 10 different adult mouse tissues showed that the six Obox family transcripts are preferentially expressed in the gonads. In situ hybridization detected Obox1 and Obox6 transcripts exclusively in oocytes as early as one-layer follicles and throughout folliculogenesis. Obox1, Obox2, Obox3, Obox4, Obox5, and Obox6 map to proximal chromosome 7 in the mouse. The Obox1 and Obox2 genomic structures revealed the presence of six exons each. The Obox genes represent a new family of tissue-specific homeobox genes preferentially expressed in gonads.

General function DNA binding
Comment
Cellular localization Nuclear
Comment
Ovarian function Oogenesis
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment
Follicle stages Primordial, Primary, Secondary, Antral, Preovulatory
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: May 24, 2002, 5:06 p.m. by: hsueh   email:
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last update: May 24, 2002, 5:06 p.m. by: system    email:



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