| MRP9; ABCC12; ABC transporter 12 | OKDB#: 1507 |
| Symbols: | MRP9; ABCC12; ABC transporter 12 | Species: | human | ||
| Synonyms: | Locus: |
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R-L INTERACTIONS MGI |
| General Comment |
Combining a computer-based screening strategy and functional genomics,
MRP9 (ABCC12), a member of the ATP-binding cassette (ABC) superfamily, was identified. Bera TK, et al 2002 show that the
gene has two major transcripts of 4.5 and 1.3 kb. In breast cancer, normal breast, and testis, the
MRP9 gene transcript is 4.5 kb in size and encodes a 100-kDa protein. The protein is predicted to
have 8 instead of 12 membrane-spanning regions. When compared with closely related ABC family
members, it lacks transmembrane domains 3, 4, 11, and 12 and the second nucleotide-binding
domain. In other tissues including brain, skeletal muscle, and ovary, the transcript size is 1.3 kb. This
smaller transcript encodes a nucleotide-binding protein of approximately 25 kDa in size.
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| General function | Channel/transport protein | |||
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| Cellular localization | Plasma membrane | |||
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| Ovarian function | ||||
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| Expression regulated by | ||||
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| Ovarian localization | ||||
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| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
| Links |
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| created: | May 26, 2002, 1:52 p.m. | by: |
hsueh email:
home page: |
| last update: | May 26, 2002, 1:52 p.m. | by: | system email: |
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