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General Comment |
Detwiler MR, et al 2001 reported that two zinc finger proteins, OMA-1 and OMA-2, are redundantly
required for oocyte maturation in C-elegans
Oocytes are released from meiotic prophase I arrest through a process termed
oocyte maturation. The authors show that two TIS11 zinc
finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing
oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2
mutants initiate but do not complete maturation and arrest at a defined point
in prophase 1. Two maturation signal-induced molecular events, including the
maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma
prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting
that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of
prophase progression during meiotic maturation.
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