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Ovarian Kaleidoscope Database (OKdb)

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OMA 1 OKDB#: 1508
 Symbols: OMA 1 Species: C. elegans
 Synonyms:  Locus:


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General Comment Detwiler MR, et al 2001 reported that two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C-elegans Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. The authors show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation and arrest at a defined point in prophase 1. Two maturation signal-induced molecular events, including the maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation.

General function DNA binding
Comment
Cellular localization Nuclear
Comment
Ovarian function Oogenesis
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: May 27, 2002, 4:14 p.m. by: hsueh   email:
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last update: May 27, 2002, 4:14 p.m. by: system    email:



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