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General Comment |
Calcitonin acts through a 7-transmembrane domain, G protein-coupled receptor
(CALCR). Another 7-transmembrane domain receptor, CGRPR , which is 55%
identical to CALCR, had been shown to act as a receptor for the CGRPs only in a
single cell line. Receptor activity-modifying protein-1 (RAMP1), however, transports
CGRPR to the cell surface and presents it as a mature glycoprotein and as a receptor
for CGRP. RAMP-3 is a paralog of RAMP-1.
NCBI Summary:
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
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