|
General Comment |
Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the
balance between the activities of protein-tyrosine kinases (PTK) and protein-tyrosine phosphatases
(PTPase). Oncogenesis can result from an imbalance. There are 2 classes of PTPase molecules: low
molecular weight proteins with a single conserved phosphatase domain such as T-cell protein-tyrosine
phosphatase (PTPT; OMIM 176887), and high molecular weight receptor-linked PTPases with 2 tandemly
repeated conserved domains separated by 56 to 57 amino acids.
NCBI Summary:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
|