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Ovarian Kaleidoscope Database (OKdb)

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Hsueh lab

HPMR

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since 01/2001:
176557

NICASTRIN OKDB#: 1591
 Symbols: NCSTN Species: human
 Synonyms: NCSTN| APH2|  Locus: 1 in Homo sapiens
HPMR


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment Nicastrin is a type 1 transmembrane glycoprotein that interacts with both presenilin-1 (PS1; see OMIM 104311) and presenilin-2 (PS2; OMIM 600759) and has a central role in presenilin-mediated processing of beta-amyloid precursor protein (beta-APP, OMIM 104760) and some aspects of notch (OMIM 190198)/glp-1 signaling in vivo. Nicastrin plays a role as regulator of Notch signaling, a component of gamma-secretase, and a regulator of presenilin localization and stabilization.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment Taft RA, et al 2002 reported the identification of genes encoding mouse oocyte secretory and transmembrane proteins by a signal sequence trap. At all stages of follicular development, oocytes interact with surrounding granulosa cells and promote their differentiation into the types of cells that support further oocyte growth and developmental competence. These interactions suggest the existence of an oocyte-granulosa cell regulatory loop that includes both secreted proteins and cell surface receptors on both cell types. Factors involved in the regulatory loop will therefore contain a signal sequence, which can be used to identify them through a signal sequence trap (SST). A screen of an oocyte SST library identified three classes of oocyte-expressed sequences: known mouse genes, sequences homologous to known mammalian genes, and novel sequences of unknown function. Many of the recovered genes may have roles in the oocyte-granulosa cell regulatory loop. For several of the known mouse genes, new roles in follicular development are implied by identification of their expression, for the first time, in the oocyte. Nicastrin was found by the SST screen.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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created: Aug. 26, 2002, 3:08 p.m. by: hsueh   email:
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last update: Jan. 15, 2004, 1:56 p.m. by: system    email:



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