RAN (Ras-related nuclear protein) is a small GTP-binding protein belonging to the RAS superfamily (see OMIM 190020)
that is essential for the translocation of RNA and proteins through the nuclear pore complex . The
RAN protein is also involved in control of DNA synthesis and of cell cycle progression. RAN BP was isolated in the yeast 2-hybrid assay using RAN as the bait.
NCBI Summary:
This gene encodes a 55-kD protein of 500 amino acid residues which is localized within the centrosome throughout the cell cycle. Mouse, hamster, and human forms of this protein are identical. This protein is localized within the central part of microtubule asters and is involved in microtubule nucleation and regulation of the centrosome by RAN.
General function
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Cellular localization
Plasma membrane
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Ovarian function
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Expression regulated by
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Ovarian localization
Oocyte
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Taft RA, et al 2002 reported the identification of genes encoding mouse oocyte secretory and
transmembrane proteins by a signal sequence trap.
At all stages of follicular
development, oocytes interact with surrounding granulosa cells and promote their
differentiation into the types of cells that support further oocyte growth and
developmental competence. These interactions suggest the existence of an
oocyte-granulosa cell regulatory loop that includes both secreted proteins and cell
surface receptors on both cell types. Factors involved in the regulatory loop will
therefore contain a signal sequence, which can be used to identify them through a
signal sequence trap (SST). A screen of an oocyte SST library identified three
classes of oocyte-expressed sequences: known mouse genes, sequences homologous
to known mammalian genes, and novel sequences of unknown function. Many of the
recovered genes may have roles in the oocyte-granulosa cell regulatory loop. For
several of the known mouse genes, new roles in follicular development are implied
by identification of their expression, for the first time, in the oocyte.
RANBP9 was found by the SST screen.