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Ovarian Kaleidoscope Database (OKdb)

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SREBP CLEAVAGE-ACTIVATING PROTEIN OKDB#: 1596
 Symbols: SREBP CLEAVAGE-ACTIVATING PROTEIN Species: human
 Synonyms: SCAP|  Locus:


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General Comment Cholesterol homeostasis in animal cells is achieved by regulated cleavage of SREBPs, membrane-bound transcription factors. Proteolytic release of the active domains of SREBPs from membranes requires a sterol-sensing protein called SCAP, which forms a complex with SREBPs.

General function
Comment
Cellular localization Other Membrane
Comment
Ovarian function Steroid metabolism
Comment
Expression regulated by
Comment
Ovarian localization Oocyte
Comment Taft RA, et al 2002 reported the identification of genes encoding mouse oocyte secretory and transmembrane proteins by a signal sequence trap. At all stages of follicular development, oocytes interact with surrounding granulosa cells and promote their differentiation into the types of cells that support further oocyte growth and developmental competence. These interactions suggest the existence of an oocyte-granulosa cell regulatory loop that includes both secreted proteins and cell surface receptors on both cell types. Factors involved in the regulatory loop will therefore contain a signal sequence, which can be used to identify them through a signal sequence trap (SST). A screen of an oocyte SST library identified three classes of oocyte-expressed sequences: known mouse genes, sequences homologous to known mammalian genes, and novel sequences of unknown function. Many of the recovered genes may have roles in the oocyte-granulosa cell regulatory loop. For several of the known mouse genes, new roles in follicular development are implied by identification of their expression, for the first time, in the oocyte. SCAP was found by the SST screen.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Aug. 26, 2002, 3:39 p.m. by: hsueh   email:
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last update: Aug. 26, 2002, 3:39 p.m. by: system    email:



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