| G protein-coupled receptor 62 | OKDB#: 1612 |
| Symbols: | GPR62 | Species: | human | ||
| Synonyms: | GPCR8, KPG_005, MGC26943, | Locus: | 3p21.1 in Homo sapiens | HPMR |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
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| General Comment |
Lee et al. (2001) identified GPR62 within human genomic DNA using GPR61 (OMIM 606916) as probe. Primers to the
intronless sequence were synthesized, and GPR62 cDNA was amplified by PCR and cloned. The deduced 368-amino
acid protein shares 44% sequence similarity with GPR61 in the transmembrane domain. Northern blot analysis
revealed a single 2.3-kb transcript in all brain regions examined, including basal forebrain, frontal cortex, thalamus, caudate, and putamen. No expression was detected in liver. THis orphan receptor was found in a human ovary cDNA library.
NCBI Summary: G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005] |
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| General function | Receptor | ||||
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| Cellular localization | Plasma membrane | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Sept. 13, 2002, 8:53 a.m. | by: |
hsueh email:
home page: |
| last update: | Oct. 25, 2011, 4:32 p.m. | by: | hsueh email: |
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