Maisonpierre et al. (1993) identified 2 novel
members of the Eph family of receptor tyrosine kinases in rat and named them 'EPH homology kinase' (Ehk)-1 (600004)
and -2. Analysis of Ehk1 cDNAs from various brain libraries demonstrated that alternatively spliced transcripts can encode
5 different forms of Ehk1 transmembrane protein. In contrast, analysis of Ehk2 cDNAs revealed that they encode only a
single form of protein. The structure of Ehk2 differed from all known members of the Eph family by having a 42-amino acid
insert positioned between homology regions IV and V in the kinase domain.
General function
Receptor
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Cellular localization
Plasma membrane
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Ovarian function
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Expression regulated by
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Ovarian localization
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Multiple transcripts corresponding to ehk-2 were detected by Northern blot analysis only in the mouse brain. RT-PCR analysis revealed the presence of transcripts encoding this kinase in adult mouse brain, inner ear, testes, ovary, thymus, and spleen (Lee et al., 1996).