The GP IIb/IIIa complex belongs to a class of receptors that bind cell adhesion molecules. They share a common
heterodimeric structure with alpha and beta subunits.
General function
Cell adhesion molecule
Comment
Cellular localization
Extracellular Matrix
Comment
Ovarian function
Luteinization
Comment
Expression regulated by
Comment
Ovarian localization
Oocyte, Theca, Luteal cells, Stromal cells
Comment
Owens GE, et al 2002 reported the characterization of integrin expression in the mouse ovary.
Integrin alpha:beta heterodimers mediate cell contacts to the extracellular matrix and
initiate intracellular signaling cascades in response to a variety of factors. Integrins
interact with many determinants of cellular phenotypes and play roles in controlling
the development, structural integrity, and function of every type of tissue. To determine their
relevance to ovarian physiology, the authors have studied the expression of integrin subunit
mRNAs by Northern blot analysis and in situ hybridization in ovaries of wild-type,
growth differentiation factor 9 (Gdf 9) knockout, FSHbeta (Fshb) knockout, and
inhibin alpha (Inha) knockout mice.
Integrin beta(3) mRNA is expressed in theca and interstitial
cells and is upregulated in corpora lutea. It is nearly undetectable in
ovaries of Fshb knockout mice, which develop preantral follicles but have no
luteal cells.
Follicle stages
Primordial, Corpus luteum
Comment
Arraztoa JA, et al 2005 reported the identification of genes expressed in primate primordial oocytes.