Using PCR to screen brain cDNA, De Moerlooze et al. (2000) obtained a cDNA encoding the human ortholog of the mouse Gir gene, or GPR83. The 4-exon human gene produces a deduced 423-amino acid protein, approximately 90% identical to the mouse sequence. This is an orphan receptor.
General function
Receptor
Comment
Cellular localization
Plasma membrane
Comment
Ovarian function
Ovulation
Comment
Expression regulated by
LH
Comment
Ovarian localization
Theca
Comment
The differential display procedure revealed ovarian transcription of an mRNA that codes for this G-protein-coupled receptor (GPCR) in hthe theca cells after hCG inductionof ovulation (Espey et al 2002 ). The ligand for this receptor has not been identified, and there is almost no information about the properties and functions of this membrane receptor. A recent study of this GPCR in rat brain indicates that the receptor is a 422-amino acid protein that is induced by glucocorticoids Wang et al 2001 . However, the regulation of this receptor in the ovary and its potential role in the ovulatory process remain to be determined.