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HPMR

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G PROTEIN-COUPLED RECEPTOR 83; GPR83 OKDB#: 1659
 Symbols: G PROTEIN-COUPLED RECEPTOR 83; GPR83 Species: human
 Synonyms: GIR, MOUSE, HOMOLOG OF, GIR|  Locus: 11q21 in Homo sapiens
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General Comment Using PCR to screen brain cDNA, De Moerlooze et al. (2000) obtained a cDNA encoding the human ortholog of the mouse Gir gene, or GPR83. The 4-exon human gene produces a deduced 423-amino acid protein, approximately 90% identical to the mouse sequence. This is an orphan receptor.

General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Ovulation
Comment
Expression regulated by LH
Comment
Ovarian localization Theca
Comment The differential display procedure revealed ovarian transcription of an mRNA that codes for this G-protein-coupled receptor (GPCR) in hthe theca cells after hCG inductionof ovulation (Espey et al 2002 ). The ligand for this receptor has not been identified, and there is almost no information about the properties and functions of this membrane receptor. A recent study of this GPCR in rat brain indicates that the receptor is a 422-amino acid protein that is induced by glucocorticoids Wang et al 2001 . However, the regulation of this receptor in the ovary and its potential role in the ovulatory process remain to be determined.
Follicle stages Preovulatory
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Nov. 21, 2002, 5:32 a.m. by: hsueh   email:
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last update: Nov. 21, 2002, 5:32 a.m. by: system    email:



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