Genes of the MAGE family direct the expression of tumor antigens that are recognized on a human melanoma by autologous cytolytic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors, and based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. However, although a large number of MAGE genes have now been identified and extensively studied in tumors of various origin, their functions in normal cells remain unknown.
General function
Receptor
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Cellular localization
Plasma membrane
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Ovarian function
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Expression regulated by
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Ovarian localization
Tumor cells
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Jungbluth AA, et al 2002 reported that CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues, including ovarian carcinomas.