| Protein-tyrosine Phosphatase, Receptor-type, F | OKDB#: 1756 |
| Symbols: | PTPRF | Species: | human | ||
| Synonyms: | RECEPTOR-LINKED PROTEIN-TYROSINE PHOSPHATASE LAR|LEUKOCYTE ANTIGEN-RELATED TYROSINE PHOSPHATASE, LAR| | Locus: | 1p32 in Homo sapiens | HPMR |
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| General Comment |
The LAR gene (symbolized PTPRF) encodes a membrane protein that has a cytoplasmic domain with homology to protein-tyrosine phosphatase 1B (176885) and an extracellular domain homologous to the neural cellular adhesion molecule NCAM (116930).
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| General function | Receptor | ||||
| Comment | |||||
| Cellular localization | Plasma membrane | ||||
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| Ovarian function | Follicle development | ||||
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| Expression regulated by | |||||
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| Ovarian localization | Granulosa | ||||
| Comment | Shiota M, et al.(2003) reported that Protein Tyrosine Phosphatase PTP20 Induces Actin Cytoskeleton Reorganization by Dephosphorylating p190 RhoGAP in Rat Ovarian Granulosa Cells Stimulated with Follicle-Stimulating Hormone. The authors identified 25 protein tyrosine phosphatases (PTPs) expressed in rat ovarian granulosa cells. | ||||
| Follicle stages | Antral | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | April 8, 2003, 2:12 p.m. | by: |
hsueh email:
home page: |
| last update: | Dec. 2, 2003, 11:06 a.m. | by: | system email: |
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