| Protein-tyrosine Phosphatase, Nonreceptor-type 8 | OKDB#: 1760 |
| Symbols: | PTPN8 | Species: | human | ||
| Synonyms: | PEST-DOMAIN PHOSPHATASE| PEP| | Locus: | 1p13 in Homo sapiens |
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| General Comment |
Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the balance between the activities of protein-tyrosine kinases (PTK) and protein-tyrosine phosphatases (PTPase). Oncogenesis can result from an imbalance. There are 2 classes of PTPase molecules: low molecular weight proteins with a single conserved phosphatase domain such as T-cell protein-tyrosine phosphatase (PTPT; 176887), and high molecular weight receptor-linked PTPases with 2 tandemly repeated conserved domains separated by 56 to 57 amino acids.
[Shiota M, et al $2003 $12554790] reported that Protein Tyrosine Phosphatase PTP20 Induces Actin Cytoskeleton Reorganization by Dephosphorylating p190 RhoGAP in Rat Ovarian Granulosa Cells Stimulated with Follicle-Stimulating Hormone.
The authors identified 25 protein tyrosine phosphatases (PTPs) expressed in rat ovarian granulosa cells.
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| General function | |||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | |||||
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| Expression regulated by | |||||
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| Ovarian localization | Granulosa | ||||
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| Follicle stages | Antral | ||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | April 8, 2003, 2:24 p.m. | by: |
hsueh email:
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| last update: | April 8, 2003, 2:24 p.m. | by: | system email: |
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