benign gonial cell neoplasm encodes a product with helicase activity involved in germ-cell development which is expressed in the ovary (cystoblast , cystocyte , female germline stem cell and germarium ).It interacts genetically with bam (bag-of-marble).bgcn is essential for the localization of bam protein to the fusome.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10924476
recessive female sterile. cytokinesis defective. cystoblast cell division. male spermatogenesis meiosis.
The bgcn locus affects early oogenesis: mutations cause the production of few, defective germ cells. Germ cells accumulating in bam or bgcn mutants testis most resemble amplifying germ cells, because they undergo incomplete cytokinesis and progress through the cell cycle in synchrony within a cyst. (Gonczy et al., 1997*) Germ cells lacking bgcn become trapped in a stem cell-like state. (Lavoie et al., 1999*)
Species: D. melanogaster
Mutation name: None
type: null mutation fertility: infertile - ovarian defect Comment: recessive female sterile. cytokinesis defective. cystoblast cell division. male spermatogenesis meiosis.
The bgcn locus affects early oogenesis: mutations cause the production of few, defective germ cells. Germ cells accumulating in bam or bgcn mutants testis most resemble amplifying germ cells, because they undergo incomplete cytokinesis and progress through the cell cycle in synchrony within a cyst. (Gonczy et al., 1997*) Germ cells lacking bgcn become trapped in a stem cell-like state. (Lavoie et al., 1999*)