cni is required for the induction of both posterior and dorsal follicle cell fates. cni is probably required in the oocyte for the production of the inducing signal, but as mutations do not affect grk localization to the posterior of the oocyte cni must act at a different step in the pathway. Gonzalez-Reyes et al (1995) . cni is required for Egfr signaling in oogenesis. This signaling pathway is required for dorsal ventral patterning and for the correct anterior posterior polarization of the oocyte in midoogenesis. Roth et al (1995) .
Possible orthologs : human, mouse, rat, C.elegans, X.leavis, D.rerio (http://www.ncbi.nlm.nih.gov/HomoloGene/homol.cgi?HID=107415)
General function
Intracellular protein transport, protein binding
Comment
protein localization
Cellular localization
Plasma membrane
Comment
integral to plasma membrane
Ovarian function
Oogenesis
Comment
Expression regulated by
Comment
Ovarian localization
Oocyte, germarium,nurse cell
Comment
Follicle stages
oogenesis
Comment
Phenotypes
Mutations
1 mutations
Species: D. melanogaster
Mutation name: cniAA12
type: null mutation fertility: embryonic lethal Comment: Homozygous embryos exhibit a germline-dependent ventralized phenotype. cni1/cniAA12 transheterozygotes have mutant egg chambers. Gonzalez-Reyes et al (1995) . Hemizygous eggs display possess residual dorsal appendage material and rarely a posterior micropyle. Most cniAA12/cni1 heterozygous embryos have one reduced dorsal appendage, few have a posterior micropyle, and a third of the eggs contain no embryosRoth et al (1995) .