enc is involved both in regulating the number of germline mitoses and in the process of oocyte differentiation. It interacts genetically with otu. enc is a negative regulator of bam. Hawkins et al (1996) . Disruption of bam expression in enc mutant ovaries suggests enc has a role early in cyst development. Hawkins et al (1996) . enc is also required later in oogenesis for correct dorsal ventral patterning in the egg. Post-transcriptional regulation of grk by enc is required for axis determination in Drosophila. Hawkins et al (1997) .
General function
Cell death/survival, Cell proliferation, DNA binding
Comment
Putative single-stranded nucleic acids-binding domain R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved R and histidine residues. The function of the domain is predicted to be binding ssDNA
Egg chamber formation
Oocyte dorsal/ventral axis determination
Regulation of pole plasm oskar mRNA localization
Expression regulated by
Comment
Ovarian localization
Oocyte, cyst
Comment
cystocyte, female germline stem cell
Follicle stages
oogenesis, cyst
Comment
Phenotypes
Mutations
1 mutations
Species: None
Mutation name: enc BB
type: None fertility: embryonic lethal Comment: Ovaries undergo an extra round of mitosis in the germline to produce egg chambers with an excess number of nurse cells. Some of the egg chambers are also bipolar. Homozygous females exhibit defects during oogenesis. Egg chambers either contain twice the normal number of germline cells, are bipolar exhibiting an increase in the number of germline cells and have a defect in the correct positioning of the oocyte or in a small number of cases contain less than 16 germline cells. Hawkins et al. (1996)