| SORBITOL DEHYDROGENASE; SORD | OKDB#: 1774 |
| Symbols: | SORBITOL DEHYDROGENASE; SORD | Species: | human | ||
| Synonyms: | SORBITOL DEHYDROGENASE 1, SORD1| SORBITOL DEHYDROGENASE 2, INCLUDED, SORD2, INCLUDED| | Locus: | 15q15.3 in Homo sapiens |
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| General Comment |
Sorbitol dehydrogenase (SORD; EC 1.1.1.14 ) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications. The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
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| General function | Enzyme, Oxidoreductase | ||||
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| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | Follicle development | ||||
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| Expression regulated by | |||||
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| Ovarian localization | Granulosa | ||||
| Comment | Kaneko T, et al reported colocalization of polyol-metabolizing enzymes and immunological detection of fructated proteins in the female reproductive system of the rat. The expression of aldose reductase (AR) and sorbitol dehydrogenase (SDH), which, in concert, catalyze the conversion of glucose to fructose via sorbitol, in the rat ovary, oviduct, and uterus, was investigated by immunohistochemical and biochemical analyses. The activities and protein levels of AR and SDH were higher in the ovary than in the oviduct and uterus. A strong immunoreactivity to the anti-AR antibody was observed in granulosa cells and epithelia of the oviduct, endometrium, and endometrial glands, and virtually the same tissues were strongly stained with the anti-SDH antibody. The application of an anti-fructated lysine antibody, which detects an adduct of fructose with the epsilon-amino group of lysine in proteins, in this study detected marked staining mainly in the egg and luminal surface of the oviductal epithelia. Collectively, these data indicate that fructose is produced by coordinately expressed AR and SDH in the egg and epithelia of the oviduct and suggest that the resulting sorbitol and fructose can be used as energy sources for spermatozoa motility during the fertilization process. The abundance of AR compared with SDH suggests that it also plays an additional role in the reproductive system, which might include a source of reducing power and protection against toxic carbonyl compounds. | ||||
| Follicle stages | Antral | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | April 16, 2003, 6:06 a.m. | by: |
hsueh email:
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| last update: | April 16, 2003, 6:06 a.m. | by: | system email: |
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